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The history of NMN research

While the history of NMN research is naturally intertwined with the history of NAD+, we will only list a few specific studies of note.

Back in 1963, Chambon, Weill, and Mandel discovered that NMN provided the cellular energy needed to activate an important nuclear enzyme. This led to the discovery of poly (ADP-ribose) polymerases (PARPs), a family of proteins involved in a number of cellular processes, such as DNA repair, genomic stability, and programmed cell death, which is known as apoptosis. PARPs and their activity are also linked to changes in lifespan in different species.

In 2014, a team of researchers led by Dr. David Sinclair demonstrated that NMN can extend the lifespan of mice. In 2017, researchers again led by Dr. David Sinclair used NMN to reverse DNA damage in mice by increasing NAD+ levels, thus increasing the activity of PARP so that it could repair DNA damage.

In 2020, researchers will use NMN to improve blood flow and neurovascular health in elderly mice. It also seems to reverse some age-related changes in gene expression. From a total of 590 genes that differ in young and old animals, NMN treatment reversed 204 of them back to young expression levels.

Also in 2020, a group of researchers demonstrated that treatment with NMN can restore neurovascular coupling (NVC) in elderly mice. Lack of NVC seems to be the main factor in age-related decline in cognitive and motor function.