How much NMN do I need to take to be effective? Most rodent studies have shown the effectiveness of NMN in preventing age-related diseases at a dose of about 300 mg/kg. Therefore, for a person weighing 75 kg (about 165 pounds), this is equivalent to 22,500 mg (22.5 grams). Given the cost of NMN, the cost per dose may exceed US$100, and if taken once a day, it would exceed US$35,000 per year. But large organisms like humans do not need such high doses to function. There is a scientific concept called “volume of distribution”, which means that rodents like mice require 12.3 times higher doses of substances than humans. Therefore, the dose of 300 mg/kg for mice is equivalent to the dose of 24.39 mg/kg for humans, while a person weighing 75 kg needs about 1.829 grams to achieve the same effect. Keep in mind that the 300 mg/kg dose for mice is considered a “huge” dose, and it may provide enough NMN to increase effectiveness. The question then becomes, “How much NMN does a person need to take to have a significant effect?”
Taking into account human and animal studies on effectiveness and safety and calculating the optimal NMN dose, the recommended dose for adults between 30 and 60 years old is 500 mg per day. People over 65 can safely take 750 mg a day to maximize the benefits of NMN.
David Sinclair, a professor at Harvard University who studies aging, once talked about taking NMN to maintain health and prevent aging. Dr. Sinclair said that he took 1 gram of NMN a day, along with resveratrol, metformin, and aspirin without any side effects.